The ACTIVE (Atrial Fibrillation Clopidogrel Trial with Irbesartan for the Prevention of Vascular Events) trial of 7,554 patients with atrial fibrillation in 30 countries found clopidogrel added to Aspirin significantly reduced the risk of cardiovascular events, and particularly stroke.
Two simple and accurate spectrophotometric methods were presented for the determination of binary mixtures of each of Eprosartan and Irbesartan with Hydrochlorothiazide in dosage forms.
Under the agreement terms, BMKK will sublicense to DSP the development, manufacturing/marketing and marketing rights of irbesartan, an anti-hypertension drug.
(7.) Parving HH, Lehnert H, Brochner-Mortensen J, Gomis R, Andersen S, Arner P; Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group.
(11) Angiotensin II Losartan (Cozaar), valsartan Works by blocking receptor (Diovan), irbesartan (Avapro), angiotensin II blockers and candesartan (Atacand) receptors on cells, helping reduce blood pressure.
Bristol-Myers Squib and Sanofi-Synthelabo report the FDA approval was based on results from an Irbesartan Diabetic Nephropathy Trial which demonstrated that when patients with high blood pressure, type 2 diabetes and evidence of kidney disease were treated with Avapro the risk of progression of their nephropathy or death was 20% lower than that of the placebo group and 23% lower than the group treated with amlodipine, a calcium-channel blocker.
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