In the conditioned cell culture medium from UMSCC1 cells with higher expression of miR-375, the most significantly reduced secreted proteases were a group of serine proteases known as kallikreins: kallikrein 5, kallikrein 6, kallikrein 10, and kallikrein 13.
Because measurement of PSA in serum is widely used for identifying individuals to be offered diagnostic procedures for detection of prostate cancer, it is important to know whether genetic factors may influence the non- cancer-related prostatic secretion of kallikreins. To address this question, we examined the relationship between SNPs in KLK2 and KLK3 and concentrations of hK2 and PSA in serum and seminal plasma by use of a population-based cohort of young men in whom prostate conditions are very rare.
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