A group of genes in humans and most other vertebrates that code for cell-surface glycoproteins (called MHC molecules) which function in the immune system and also are principally responsible for determining tissue compatibility in transplants.
Kretsovali, "Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes," Molecular and Cellular Biology, vol.
In humans, major histocompatibility complex controlled by the genes located on chromosome 6 is responsible for ensuring compatibility between donors and recipients.
Cathepsin S is involved in the assembly of the major histocompatibility complex II protein, and by interfering with this process, the effector T-helper cell response may be muted and T-cell interaction with B cells may be decreased.
(2) One of these risk genes, on chromosome 6, is in the major histocompatibility complex and has the strongest association with schizophrenia (P = [10.sup.-31]).
Specialized cells in the thymus interact with a molecule known as the Major Histocompatibility Complex class II (MHCII) to "teach" T cells to differentiate between normal tissues and organs, and foreign invaders.
PLX cells, and other MSC, affected complex pathways in order to prevent the priming of Type 1 T helper cell (Th1) responses towards major histocompatibility complex mismatches.
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