The European Commission has granted orphan medicinal product designation for avacopan for the treatment of two forms of ANCA-associated Vasculitis: microscopic polyangiitis and granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis), as well as for C3G.
The product has been approved to treat non-Hodgkin's lymphoma, chronic lymphocytic leukaemia, and granulomatosis with polyangiitis and microscopic polyangiitis. It targets a CD20 protein present on the surface of B cells.
Epidemiology and etiology of wegener granulomatosis, microscopic polyangiitis, churg-strauss syndrome and goodpasture syndrome: vasculitides with frequent lung involvement.
"We look forward to continuing to leverage our experience and expertise in biotechnology to bring more biosimilars to patients." ABP 798 is being developed as a biosimilar candidate to rituximab, a CD20-directed cytolytic antibody that is approved in many regions for the treatment of adult patients with moderate-to-severe rheumatoid arthritis, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, pemphigus vulgaris, granulomatosis with polyangiitis and microscopic polyangiitis.
More broad-ranging than ARAMIS, CUTIS is seeking 50 patients with several forms of idiopathic vasculitis, including cryoglobulinemic vasculitis, drug-induced vasculitis, eosinophilic granulomatosis with polyangiitis, IgA vasculitis, isolated cutaneous vasculitis, granulomatosis with polyangiitis, microscopic polyangiitis, polyarteritis nodosa, and urticarial vasculitis.
Azathioprine hypersensitivity presenting as cardiogenic shock and Sweet's syndrome in a patient with microscopic polyangiitis. Internal medicine 2012; 51: 1889-92.
It is seen in PAN, microscopic polyangiitis, Wegener's granulomatosis, Churg-Strauss syndrome, and secondary vasculitis due to rheumatoid arthritis or Sjogren's syndrome.
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