Dopamine is another
monoaminergic neurotransmitter that has attracted much attention.
This reduction in the perioperative variations in heart rate and BP may be attributed to the inhibitory action of clonidine on spontaneous as well as evoked activity of the central
monoaminergic systems involved in the modulation of nociception, cortical arousal and the sleep/wake cycle mediated by the [alpha] 2 adrenergic receptors.
Monoaminergic systems participate mainly in nonsynaptic interactions hence, NO may have an important role in the regulation of
monoaminergic systems.
Recent investigations report sex differences in some key
monoaminergic enzymes in the brain, notably monoamine oxidase-A (MAO) (a),(b) and catechol-O-methyltransferase (COMT).
The
monoaminergic systems exhibit considerable homology from one species to another.
Scheduling of
monoaminergic neurotransmitter receptor expression in the primate.
Glucocorticoid receptor antagonists and
monoaminergic antidepressants can protect against negative synaptic plasticity in CA1 induced by stress.
SCLPN may exert its antidepressant effect through a
monoaminergic mechanism
Dysregulation of
monoaminergic neurotransmitter systems caused by fluctuating estrogen levels may cause both depression and VMS.
Mikkelsen, "Temporal expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat hippocampus after treatment with selective and mixed
monoaminergic antidepressants," European Journal of Pharmacology, vol.
Previous study also demonstrated that antinociceptive effect of mitragynine is mediated through descending noradrenergic and serotonergic systems receptors suggesting that mitragynine might be able to stimulate the release of endogenous noradrenaline (NA) and serotonin (5-HT) from nerve terminals of descending
monoaminergic neuron (Matsumoto et al.
They innervate wake-promoting brain regions and produce sleep by coordinating the inhibition of the major ascending
monoaminergic arousal systems.