For example,
mucins (highly glycosylated proteins) comprise the mucus barrier gradient that provides not only a protective barrier but also regulation of host-pathogen interactions.
In preclinical studies, the AMPPLIFY technology increased delivery of loteprednol etabonate into ocular tissues more than three-fold compared to current LE products by facilitating penetration through the tear film
mucins. The AMPPLIFY technology also underpins Inveltys (loteprednol etabonate ophthalmic suspension) 1%, the first twice-a-day corticosteroid for the treatment of post-operative inflammation and pain following ocular surgery, which was approved by the FDA in August 2018.
Glycosylated proteins called
mucins line the gut wall, providing sugars that serve as attachment points for gut bacteria while also feeding them as they assist in digestion.
Excessive mucus production is a major pathological event contributing to airway obstruction, atelectasis, impairment of gas exchange, and antibiotic permeability.[1],[2]
Mucins are a family of high-molecular-weight, heavily glycosylated proteins that are the most important constituent of mucus.
In addition, those who were taking vitamin E were also found to have lower levels of proteins called
mucins, which affect the stickiness of mucus.
Based on the structure and function of a molecule,
mucin is subdivided into 3 categories: membrane-bound
mucins (MUC1, MUC3 MUC4, MUC12, MUC16, MUC17), gel-forming (secreted)
mucins (MUC2, MUC5AC, MUC5B, MUC6, MUC19), and soluble
mucin (MUC7).
Immunostaining for
mucins indicated that the NET cells expressed MUC5AC and MUC1.
The frequency of mucinous adenocarcinoma of the prostate, defined by the presence of more than 25% extravasated
mucins, is approximately 0.2% (2).
The front line of enteric host defense against unwelcome intrusion of harmful microorganisms:
mucins, antimicrobial peptides, and microbiota.
McGuckin, "
Mucins in the mucosal barrier to infection," Mucosal Immunology, vol.
Mucins are a family of high molecular weight glycosylated proteins [10] that protect epithelial cells and form the ductal surfaces of several organs [11-13].