The approval is for adjuvant, or after surgery, treatment of people with HER2-positive early breast cancer who have residual invasive disease after neoadjuvant, or before surgery, taxane and Herceptin (trastuzumab)-based treatment.
For a complete clinical evaluation of a gastric cancer specimen, a pathology report should include the type of surgery, tumor location, macroscopic type, histologic type of cancer, tumor differentiation, tumor grade, tumor pattern, invasion depth, total harvested lymph node number, metastatic lymph node number, location of metastatic lymph nodes, size of metastatic lymph nodes, presence of perineural invasion with its sizes, number of tumor deposits, location of tumor deposits, presence of lymphovascular invasion, presence of perineural invasion, presence of tumor invasion at surgical margins, margin width, the Mandard and College of American Pathologists (CAP) classifications if neoadjuvant treatment was given, and distance between the tumor and resection margins (23-25).
The company has received approval from the US Food and Drug Administration (FDA) for the post-surgery use of the product in patients with HER2-positive early breast cancer with residual disease after neoadjuvant (before surgery) treatment.
MD Anderson Cancer Center at Cooper is participating in a clinical research study to determine if certain breast cancer patients who respond positively to neoadjuvant systemic therapy can be treated without surgery.MD Anderson Cancer Center at Cooper is participating in a clinical research study to determine if certain breast cancer patients who respond positively to neoadjuvant systemic therapy can be treated without surgery.
In rectal cancer, neoadjuvant chemoradiation has a recognizable role aiming to downsize and/or downstage tumors that are at a risk of incomplete excision.
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