The conserved protein, called M2, is dwarfed by its neighbors, hemagglutinin and
neuraminidase. These capricious, larger molecules have made the flu virus a moving target.
KF918334-KF918341), whereas the sequence analysis of the other 2 samples was focused on hemagglutinin and
neuraminidase genes and a few regions of the other genes (nt 159-525 and nt 994-1107 of polymerase basic protein [PB] 2, nt 115-453 and nt 1726-2259 of PB1, nt 19-297 of nucleocapsid protein, and nt 715-981 of matrix protein) to trace the avian virus responsible for the human infections.
neuraminidase inhibitor approved in the US for the treatment of acute uncomplicated influenza in adults.
They have described how to use their newly discovered compounds to interrupt the enzyme
neuraminidase's facilitation of influenza's spread.
The
neuraminidases of HiNi viruses also are similar to a
neuraminidase in the current vaccine strain.
Amantadine and rimantadine are approved for treating influenza A, while the
neuraminidase inhibitor drugs zanamivir and oseltamivir are approved to treat both influenza A and B [6-8].
One viral protein, an enzyme called
neuraminidase, is required for the bundle to unglue itself so that individual virus particles can infect other cells.
Biota Pharmaceuticals Inc and Daiichi Sankyo had entered into a collaboration, commercialisation and license agreement to develop long-acting
neuraminidase inhibitors, including laninamivir octanoate, under which, Daiichi Sankyo has obtained exclusive marketing rights to laninamivir octanoate in Japan.
Oseltamivir, an orally administered
neuraminidase (NA) inhibitor, is the most prescribed medication for the treatment of persons with influenza virus infections.
Neuraminidase inhibitors (NAIs) are recommended for the control of severe influenza A and B infections (1).