This incidence relates to approximately 8,000 new cases per year in the United States.1 Sarcomas generally have mesodermal origin, although some are derived from the
neuroectoderm, and they are divided into two groups: bone and soft-tissue sarcomas.
The precise pathogenesis of NCM remains incompletely understood, but it is thought to be related to a congenital dysmorphogenesis of neural crest-derived pluripotent precursor cells that normally migrate from the
neuroectoderm to the meninges and skin.
The pigmented and nonpigmented ciliary epithelium derives from the
neuroectoderm, while the ciliary muscles and the stroma derive from the neural crest cells.
All these stem from precursors in the
neuroectoderm, and they are all called neuroectodermal tumors of the ovary.
Primitive neuroectodermal tumors (PNETs, also called extraskeletal Ewing sarcomas [ESs]) are rare malignant tumors derived from
neuroectoderm, belonging to the group of small blue round cell tumor (SBRCT).[1],[2],[3] The body sites in which PNETs commonly grow include the central nervous system, soft tissues, and bones.
Encephalocele from midline defects and embryonic origin nasal glioma are similar and are related to the abnormal partition of the ectoderm and
neuroectoderm during the development of the nose (2).
The mouse
neuroectoderm cell line, NE-4C (ATCC[R] CRL2925[TM]), was cultured in ATCC-formulated Eagle's minimum essential medium (ATCC) supplemented with L-glutamine (2mM) and 10% fetal bovine serum.
Abnormalities of the tissues and organs in this disease are derived from the ectoderm and
neuroectoderm; actually, it is a kind of ectodermal dysplasia.
Namboori et al., "MiR-135b is a direct PAX6 target and specifies human
neuroectoderm by inhibiting TGF-[beta]/BMP signaling," The EMBO Journal, vol.
The retina develops from the
neuroectoderm, thus, like any other CNS tissue, presents a low regeneration potential.
In mammals, it is produced by cells derived from neural crest and
neuroectoderm, that is, melanocytes, eye pigment epithelium, and neurons.