In terms of regenerative medicine, iMSCs acquired a secretome similar to that of primary MSCs, thus highlighting their ability to act via
paracrine signaling.
Stem cells and stem cell therapy work by
paracrine signaling to create the appropriate healing environment to restore tissue.
PGR regulates implantation, decidualization, and glandular development via a complex
paracrine signaling network [3-5].
The activity of PB4188 was unaffected by increasing concentrations of HRG, the ligand for HER3 which mirrors the autocrine or
paracrine signaling environment of the tumor, in contrast to monoclonal antibodies against the same targets, tested as single agents or in combination.
Roarty, "
Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity?," (in Eng), Breast Cancer Res, vol.
Proposed
paracrine signaling with TNIP1 regulation in psoriasis where nonimmune cells are keratinocytes [111].
Differentiation and
paracrine signaling have both been implicated with mechanisms by which MSCs improve tissue repair.
However, estrogen does not directly act on endometrial mesenchymal stem cells, but influence stem cells via
paracrine signaling to promote endometrium regrowth.[33] Moreover, TAZ can be activated by estrogen.[34] These observations suggested that estrogen regulates endometrial stem cell differentiation via the Hippo pathway.
Heasley, "Autocrine and
paracrine signaling through neuropeptide receptors in human cancer," Oncogene, vol.
Blit et al., "Human Wharton's jelly mesenchymal stem cells promote skin wound healing through
paracrine signaling," Stem Cell Research and Therapy, vol.