Guo et al., "Inhibition of LSD1 by
pargyline inhibited process of EMT and delayed progression of prostate cancer in vivo," Biochemical and Biophysical Research Communications, vol.
Specific activity was determined in the presence of
pargyline hydrochloride.
1,3-Ditolylguanidine (DTG), clozapine, GBR12909,
pargyline and dopamine were purchased from Sigma Chemical Co.
Central serotonin level dependent changes in body temperature following administration of tryptophan to
pargyline and harmaline- pre treated rats.
Exogenous analogues of these compounds are antidepressants such as
pargyline, deprenyl, and so on.
Pargyline prevents MPTP-induced parkinsonism in primates.
Addition of the monoamine oxidase inhibitor
pargyline together with BH4 also did not increase serotonin levels (n = 3, Fig.
Certain medications (phenelzine,
pargyline, corticosteroids) can also precipitate similar symptoms, as can a host, of disorders of the hepatic, renal, hematologic, and endocrine systems, and malignancies.
Isoform-specific irreversible inhibitors include clorygline, which is a research compound specific for MAO-A, and the two B-selective inhibitors selegiline and
pargyline. Reversible MAO inhibitors include moclobemide, brofaromine, toloxatone, and befloxatone, all of which are specific for MAO-A.
Three studies used a monoamine oxidase inhibitor (deprenyl and
pargyline [Eutonyl]), and the others tested more commonly used antidepressants, including desipramine (Norpramin), bupropion (Wellbutrin), venlafaxine (Effexor), fluoxetine (Prozac), and sertraline (Zoloft).