Notably, there were six L-CMD patients who showed muscular dystrophic change with multifocal inflammatory cell infiltration in the endomysium or in the perivascular region of the
perimysium (patients No.
Also, alkaline phosphatase staining of the
perimysium was suggestive of an immune disorder.
The myopathic lesions have been shown to include multiple rounded muscle fibers with internalized nuclei [2,4,22] coupled with a diffuse thickening of endomysium and
perimysium and loose collagen-rice connective tissue separating muscle fibers [6,8,22].
Meat tenderness originates in structural and biochemical properties of skeletal muscle fibres, especially myofibrils and intermediate filaments, and of the intramuscular connective tissue, (the endomysium and
perimysium), which are composed of collagen fibrils and fibers.
Irisin is secreted mainly in skeletal muscle, especially in the
perimysium, endomysium, and nuclear parts, albeit adipose tissue, pancreas, sebaceous glands, and cardiac muscle have been identified as secretory tissues.
(2011) reported that decrease of muscle stiffness was caused by increasing the flexibility and movement of the aponeurosis and the connective tissue, e.g., endomysium,
perimysium, and epimysium, instead of lengthening muscle fiber.
Both DMD and DGR present progressive clinical signs and severe myopathy with initial fiber necrosis and regeneration associated with connective tissue proliferation in the endomysium and
perimysium (VALENTINE et al., 1990,; MIJAZATO et al., 2011b; KORNEGAY et al., 2012).
Changes to the viscosity of HA causes densification of tissue and can modify the function of fascia, nerve receptors, muscle layers (epimysium and
perimysium gliding) and hydrodynamic properties of connective tissue.
Muscle fiber necrosis and regeneration and mild inflammatory cell infiltration in the perivascular region of
perimysium can be observed.
Caption: Figure 2: Transverse (a) and longitudinal (b) hematoxylin and eosin-stained histologic sections showing an infiltrate of intermediate-sized to large lymphoid cells in the endomysium between muscle fibers and the
perimysium investing the fascicles or bundles of these fibers; these slides were prepared from the gluteal muscle biopsy of the 17-year-old boy described in case 1.