The tumour typically develops early in the course of HIV infection, coincident with symptoms of persistent generalized lymphadenopathy and before circulating CD4+ T cell numbers begin to fall.
In the early 1980s, homosexual men, many of whom had been previously diagnosed with Kaposi sarcoma or an opportunistic infection, were found to have unexplained, persistent generalized lymphadenopathy of unknown cause, which showed hyperplastic features on biopsy.
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