pro·throm·bin

(prō-thrŏm′bĭn)

A plasma protein that is converted into thrombin during blood clotting.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

prothrombin

(prəʊˈθrɒmbɪn)

(Biochemistry) biochem a zymogen found in blood that gives rise to thrombin on activation. See also phylloquinone

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

pro•throm•bin

(proʊˈθrɒm bɪn)

n.

a plasma protein involved in blood coagulation that is converted to thrombin.

[1895–1900]

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

prothrombin - a protein in blood plasma that is the inactive precursor of thrombin

factor II

clotting factor, coagulation factor - any of the factors in the blood whose actions are essential for blood coagulation

Translations

pro·throm·bin

n. protrombina, una de las cuatro proteínas principales del plasma junto a la albúmina, la globulina y el fibrinógeno.

English-Spanish Medical Dictionary © Farlex 2012

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References in periodicals archive

The negative association between Prothrombin G20210A polymorphism and the risk of RVO was mainly detected in Caucasian populations.

Genetic correlation between Prothrombin G20210A polymorphism and retinal vein occlusion risk

Thrombocyte count, clotting time, prothrombin time (PT), thrombin time (TT), active partial thromboplastin time (aPTT) and buccal mucosa bleeding time (BMBT) are the most frequently used parameters in determining coagulation disorders (Forsythe and Willis, 1989; ogurtan et al., 2002; Smith et al., 2005).

Effects of Diazepam/Propofol and Diazepam/Remifentanil Induction Protocols on the Coagulation in Dogs

This review highlighted the pharmacological characteristics of various reversal agents including Prothrombin complex concentrate, Activated Prothrombin complex concentrate, Recombinant factor VIIa, Andexanet alfa, and Ciraparantag used in the treatment of laboratory parameters prothrombin time (PT) and clotting time (CT) for the reversal of rivaroxaban.

Reversal Agents for Oral Anticoagulant Rivaroxaban

[USPRwire, Wed Oct 24 2018] Prothrombin complex concentrate is a combination of blood clotting factors used to treat and prevent bleeding in patients having factor IX deficiency.

Some of the players in the Prothrombin complex concentrate market are CSL Behring, China Biologic Pr

Current guidelines recommend the use of 4-factor prothrombin complex concentrate (4F-PCC) over fresh frozen plasma for the emergent correction of coagulopathy in patients with vitamin K antagonist (VKA)-associated major bleeding.

Comparison of outcomes in patients with intracranial hemorrhage on factor Xa inhibitors versus vitamin K antagonists treated with 4-factor prothrombin complex concentrate

Objective: To determine the frequency of prothrombin gene mutation in venous thromboembolism in our population.

FREQUENCY OF PROTHROMBIN GENE MUTATION IN VENOUS THROMBOEMBOLISM IN NORTHERN PAKISTAN

However, the patient was found to have a heterozygous prothrombin G20210A (factor II) mutation.

Brachial artery thrombosis mimicking De Quervain's syndrome: a case report

Ganzert et al [4] retrospectively analysed the outcome of a large series of amatoxin intoxication cases and found that predictors of death were the prothrombin time in combination with the serum creatinine level on 3-10 days after ingestion.

Mushroom poisoning induced acute liver failure with deranged coagulation profile

It is known that mutations in the prothrombin gene are a risk factor for thrombosis.

The c.1787G>T and c.1787G>A mutations are not found in the prothrombin gene in a Spanish population

Research variables were AST/ALT ratio, prothrombin time, platelet conunt, serum albumin and serum bilirubin.

PROGRESSION OF SERUM MARKERS IN CHRONIC LIVER DISEASE PRODUCED BY CHRONIC VIRAL HEPATITIS B, C AND CO-INFECTION

Her thrombophilia work-up was positive for a prothrombin G20210A gene mutation in heterozygous form.

Acute Unilateral Renal Infarction in the Setting of an Inherited Thrombophilia and Atrial Septal Defect