Release date- 26082019 - The first evidence was recently presented demonstrating how the immune system can be controlled by directly
reprogramming connective tissue cells into immune cells.
Researchers now report that using the measles virus vector, they've trimmed that multivector process with four
reprogramming factors down to a single "one cycle" vector process.
Until now,
reprogramming has only been possible by introducing the critical genes for the conversion, called Yamanaka factors, artificially into skin cells where they are not normally active at all.
Technology for cellular
reprogramming and its applications to the cancer epigenome
Current cell therapies are focused on three main approaches: (1) induction of endogenous cardiomyocytes to undergo proliferation and repopulate the damaged myocardium, (2) transplantation of cardiovascular progenitor cells (CPCs) or cardiomyocytes generated through the differentiation of pluripotent stem cells, and (3) direct
reprogramming of somatic cells to cardiomyocytes or expandable CPCs without transitioning through a pluripotent intermediate.
Now that we have confirmed that it's possible to reprogram wound cells to a very early stage of development we need to study if they can turn into more mature cell types and then study them in our 3D models to see if they will improve healing of chronic wounds," said Behzad Gerami-Naini, Ph.D., first author on the study in Cellular
Reprogramming and an assistant professor at Tufts University School of Dental Medicine.
Typically, to prod a skin cell into becoming a stem cell, scientists deliver into the host skin cell genes for making the four
reprogramming proteins.
Human cells company Cellular Dynamics International (NasdaqGM:ICEL) revealed on Wednesday the receipt of three patents based on the
reprogramming of human cells into pluripotent stem cells from human blood from the US Patent and Trademark Office (PTO).
By genetic
reprogramming, matured human cells, usually blood cells, can be transformed into hiPSCs.