The retina had marked outer retinal atrophy, vacuolization (
retinoschisis), and M tiller cell hypertrophy characterized by numerous optically empty, variably sized vacuoles that expanded and completely distorted and partially effaced the outer retina (
retinoschisis) (Fig 6).
AN INCREASING WORKLOAD THE AOP LEGAL & REGULATORY 2017 2018 TEAM'S CASELOAD SUBSTANTIVE HEARINGS 16 19 DAYS AT SUBSTANTIVE HEARINGS 39 53 SUBSTANTIVE REVIEW HEARINGS 6 11 TOTAL ENQUIRIES 4305 5074 AOP CIVIL CLAIM BREAKDOWN CONDITION 2017 2018 ANEURYSM 0 1 CARCINOMA 1 1 CATARACTS 2 3 CHOROIDAL MELANOMA 2 0 CORNEAL TRANSPLANT 3 0 CUSTOMER SERVICE 1 0 DEFAMATION 0 3 DRY AMD 2 0 FUNDUS LESION 1 0 GLAUCOMA 8 10 INCORRECT PRESCRIPTION 2 1 INFECTION 0 1 KERATITIS 1 0 KERATOCONUS 5 2 LASER SURGERY 1 2 MENINGIOMA 0 1 ORBITAL OSTEOMA 2 0 PAPILLOEDEMA 0 1 PITUITARY TUMOUR 1 1 POSTERIOR VITREOUS DETACHMENT 0 1 POSTERIOR SYNECHIAE 0 0 RETINAL DETACHMENT 12 2 RETINAL PROBLEM 0 1
RETINOSCHISIS 1 0 STROKE 1 0 TUMOUR 3 1 UVEITIS 1 2 WET AMD 2 1 TOTAL 52 35
Applied Genetic (AGTC) reported topline interim six-month data from its Phase 1/2 clinical trial of rAAV2tYF-CB-hRS1, an investigational AAV-based gene therapy delivered via intravitreal injection for X-linked
retinoschisis,or XLRS, due to mutations in the RS1 gene.
Farrell, whose field of vision is impaired due to congenital
retinoschisis, is also a motivational speaker on overcoming adversity.
(3) The fact that these two conditions manifest with very different clinical phenotypes make it difficult to distinguish them from other diseases on the retinal degenerative disease spectrum such as retinitis pigmentosa, congenital
retinoschisis, and secondary pigmentary retinopathy.
Patients with history of hypertension or diabetes, confounding ocular disease, additional eye operations, including vitreoretinal or cataract surgery or refractive surgeries, and other myopic complications (including lacquer cracks, posterior staphyloma, choroidal atrophy, choroidal neovascularization, subretinal hemorrhage, macular traction, macular hole, retinal detachment, and
retinoschisis) were excluded.
Mr Terry has X-linked juvenile
retinoschisis, a degenerative disorder which affects the retina and impairs the sharpness of vision in both eyes.
XLRP is one of two lead development programmes under a collaboration agreement with Biogen, along with X-linked
retinoschisis.
Those patients who have pseudophakic RD unable to describe exact time of onset of visual loss macula not involved evaluation not possible re-detachment with or without PVR
Retinoschisis Giant Retinal Tear Vitreous hemorrhage and prior or coexistent ocular disease/surgery were not included in our study.