In 1967, Comings and coworkers (2) reported a case of familial multifocal fibrosclerosis, which presented with features of retroperitoneal fibrosis, mediastinal fibrosis, sclerosing cholangitis, Riedel's thyroiditis, and pseudotumor of the orbit; these symptoms were all thought to be different manifestations of one disorder.
The German surgeon Bernhard Moritz Carl Ludwig Riedel first described Riedel's thyroiditis in 1883, as a rare disease which changes the thyroid parenchyma texture into an extremely hard lesion with adhesion to the trachea and obstructive symptoms [1].
Other common presentations include Riedel's thyroiditis, autoimmune pancreatitis, sclerosing cholangitis, sialadenitis, dacryoadenitis, periaortitis, an eosinophilic rash, and pseudotumor of the lung, lymph nodes, or orbits.
Tamoxifen also used in the other treatments like McCune-Albright syndrome, Infertility, Gynecomastia, Angiogenesis, Gene Expression, Riedel's Thyroiditis.
(5,14) Since then, many medical conditions such as Mikulicz's syndrome, Kuttner tumor, and Riedel's thyroiditis which were known as organ-specific disorders are considered as part of IgG4-related disease spectrum.
The complications of MD include autoimmune pancreatitis, retroperitoneal fibrosis, tubulointerstitial nephritis, autoimmune hypophysitis, and Riedel's thyroiditis, all of which show elevated serum immunoglobulin G4 (IgG4) levels and prominent infiltration of IgG4-positive plasmacytes.
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