Immunophenotypic and viral (human papillomavirus) correlates of vulvar
seborrheic keratosis. Hum Pathol.
When our case first visited the office, the 'polyp' configuration led us to benign-looking differential diagnosis, including pigmented nevus, strangulated fibroepithelial polyps (acrochordons), or
seborrheic keratosis, whereas BCC was not the straightforward consideration.
The dermatologist had previously diagnosed it as a
seborrheic keratosis (SK), for which Alan declined treatment.
The American Academy of Dermatology says a
seborrheic keratosis may seem worrisome because it can look like a wart, a precancerous skin growth or even skin cancer.
Actinic keratosis [36],
seborrheic keratosis [35],poroma [35], lichen planus like keratosis [24], nevi [24], hemangioma [24], inverted follicular keratosis [24], squamous intraepithelial neoplasia (SIN) [24], and sebaceous adenoma/hyperplasia [24] are a wide variety of epithelial skin disorders that have been proven to give negative results on BerEP4 testing (Table 2).
It is a targeted treatment applied directly to the raised
seborrheic keratosis using a pen-like applicator.
It is also reported that a few cases of classic BD arise in the preexisting skin lesions such as
seborrheic keratosis.[2] Histologically, pagetoid BD is characterized by nests of atypical keratinocytes with round nuclei and abundant pale cytoplasm located either singularly or in groups within the epidermis, and the main differential diagnosis of pagetoid cells includes extra-mammary pagetoid disease (EMPD) and malignant melanoma in situ (MIS).
"It was just a
seborrheic keratosis, not even precancerous.
These include
seborrheic keratosis, actinic keratosis, and cutaneous malignancies such as Bowen's disease and squamous cell carcinoma (SCC) after sun exposure of over 20 to 30 years (2).
As Fordyce angiokeratoma could be confused with benign and malignant lesions, such as basal cell carcinoma, vulvar intraepithelial neoplasia, pyogenic granuloma, condyloma acuminata and
seborrheic keratosis, histopathological evaluation is the main criterion for diagnosis (5).
Nevertheless FAD has been observed as an incidental finding in several skin lesions such as compound and junctional nevi, scars,
seborrheic keratosis, basal cell carcinoma, and squamous cell carcinoma [5].