(18.)
Sporanox [package insert], Titusville, NJ: Janssen Pharmaceuticals.
Oral medications, which include terbinafine (Lamisil) and itraconazole (
Sporanox), are taken for three months when the infection involves the toenails.
I believe that Pulmazole has the potential to significantly improve upon both the efficacy and safety profile of oral
Sporanox, and I look forward to working with the other members of the advisory board to assist Pulmatrix in advancing the development of Pulmazole to treat patients with fungal asthma, focusing initially on ABPA," stated Dr.
In the pharmacokinetic analysis of the data available, maximum sputum itraconazole concentrations were approximately 50-fold higher following inhalation dosing of 20 mg of Pulmazole compared to oral
Sporanox dosing of 200 mg.
Given concerns regarding possible aspiration pneumonia, pulmonary edema, and air sacculitis, the bird was treated with furosemide (2 mg/kg IM as needed) for 4 days, N-acetyl-L-cysteine (20 mg/ mL, 60 mg nebulized in 3 mL water q8h) for 3 days, amoxicillin trihydrate/clavulanate potassium (125 mg/kg PO ql2h, Clavamox drops; Zoetis, Inc, Kalamazoo, MI, USA) for 7 days, and itraconazole (5 mg/kg PO ql2h,
Sporanox; Janssen Pharmaceuticals, Titusville, NJ, USA) for 7 days.
Earlier in his career, he was involved in the launch of
Sporanox, Janssen's oral itraconazole product to treat fungal infections.
For fungal keratitis, all patients received 0.5% natamycin drops (Natacyn, Alcon Laboratories Inc., Belgium) 4 times daily for 4 weeks and oral itraconazole capsules (
Sporanox, Janssen Ltd., Xi'an, China) 200 mg daily for 3 weeks.
Carbamazepine * Tegretol Clarithromycin * Biaxin Clozapine * Clozaril Doxepin * Silenor Indinavir * Crixivan Itraconazole *
Sporanox Ketoconazole * Nizoral Mirtazapine * Remeron Phenytoin * Dilantin Pimavanserin * Nuplazid Quetiapine * Seroquel Rifampin * Rifadin Trazodone * Desyrel, Oleptro
For example, there is increasing interest in using the approved antifungal medicine itraconazole (
Sporanox) as a treatment for cancer.
Introduced to the market under the brand name
Sporanox, itraconazole is a highly lipophilic chemical entity that is able to penetrate into the nail plate very well.
This product is the generic version of Janssen Pharmaceutical Inc.'s
Sporanox and is indicated for the treatment of fungal infections that begin in the lungs.