sub·til·i·sin

(sŭb-tĭl′ĭ-sĭn)

Any of several extracellular enzymes produced by bacteria of the genus Bacillus that catalyze the breakdown of proteins into polypeptides and are widely used in detergents and cleaning products.

[New Latin (Bacillus) subtīlis, bacterial species to which were assigned the bacteria from which a subitilisin was first isolated (now known to be B. amyloliquefaciens); see subtilin + -in.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

subtilisin

(sʌbˈtɪlɪsɪn)

any of various protease enzymes originally derived from Bacillus subtilis

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

References in periodicals archive

The multi-enzyme formulation is subtilisin free and has been independently tested and classified as non-irritating to both the eyes and skin.

Belimed secures instrument cleaners agreement with Premier

TUESDAY, July 23, 2019 (HealthDay News) -- Patients with rejected or abandoned prescriptions for proprotein convertase subtilisin kexin type 9 inhibitors (PCSK9i) have a significantly increased risk for cardiovascular events than those with paid prescriptions, according to a study published online July 23 in Circulation: Cardiovascular Quality and Outcomes.

CV Event Risk Up With Rejected, Abandoned PCSK9i Prescriptions; Rejection rates higher for PCSK9i prescriptions for women, racial minorities, lower-income groups

Description: Aqueous solution of subtilisin with 50-53%, 1,2 propanediol

NEW INGREDIENTS FOR HOUSEHOLD CLEANERS: Here's a list of new ingredients introduced by industry suppliers in the past 12 months. For more information on any of the products listed here, contact the supplier directly using the information provided

The discovery of proprotein convertase subtilisin kexin 9 (PCSK9) by Abifadel et al.

Cardiovascular Outcomes of PCSK9 Inhibitors: With Special Emphasis on Its Effect beyond LDL-Cholesterol Lowering

The RXRR sequence has been predicted as a consensus sequence in the Vtg protein for the recognition site by furin, a proprotein-converting enzyme that is structurally related to bacterial subtilisin (Hosaka et al., 1991).

Complexity of yolk proteins and their dynamics in the sea star Patiria miniata

Enter a new class of drugs--proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors--which, according to a Cleveland Clinic expert, have the potential to change the landscape of LDL management and, possibly, cardiovascular risk reduction.

A new option for cutting 'bad' cholesterol levels: if you're at high risk and can't tolerate or reduce your LDL enough with statins, the PCSK9 inhibitors may be for you

To do this they are developing injectable monoclonal antibodies against a newly discovered protein known as proprotein convertase subtilisin kexin 9, which dramatically reduces the amount of LDL cholesterol circulating in the bloodstream.

Cholesterol-lowering injectables: more harm than good?

Results: The results demonstrated that aprE gene would not be able to produce further active subtilisin E.

Inactivation of aprE Gene in Bacillus subtilis 168 by homologus recombination: mohammed rcibbani*, safoura soleymani, hamid mirmohammad sadeghi, narjes soleimani, and fatemeh moazen

antarctica strain PI12 with nine other subtilisin serine proteases from different families is shown in Table 2.

Molecular cloning and optimization for high level expression of cold-adapted serine protease from antarctic yeast Glaciozyma antarctica PI12

solani isolate from tomato in medium, containing heat-stable potato proteins, due to the presence among these proteins of a large amount trypsin and subtilisin inhibitors [34, 35].

Serine proteinases secreted by two isolates of the fungus alternaria solani

The subtilisin protease family Pr1 is the main enzyme produced by entomopathogenic fungi during the infection process, although the trypsin- like protease Pr2 is the first to appear during in vitro growth on the cuticle (Gillespie et al., 1998).

Production and Regulation of Extracellular Proteases from the Entomopathogenic Fungus Metarhizium anisopliae (Cordycipitaceae; Hypocreales) in the Presence of Diamondback Moth Cuticle

Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease.

Identification of four novel LDL receptor gene mutations in the north-west Moroccan population