Succinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients.
CBT are associated with mutation of
Succinate Dehydrogenase Complex (SDHx) gene17.
Taking into account the patient's age, family history, the size of the tumour and the presence of metastases, the specimen was referred to the Department of Pathology at Brigham and Women's Hospital, Harvard Medical School in Boston, Massachusetts, for immunohistochemistry for
succinate dehydrogenase subunit proteins, as this was not available in South Africa at the time.
The
succinate dehydrogenase enzyme is also known as Complex II in the mitochondrial electron transport chain, and consists of four subunits (A-D), with subunits B, C and D associated with PCC and PGL.
Stratakis, "
Succinate dehydrogenase (SDHx) mutations in pituitary tumors: could this be a new role for mitochondrial complex II and/or Krebs cycle defects?," Endocrine-Related Cancer, vol.
Succinate dehydrogenase is a heterotetrameric complex composed of 4 subunits, SDHA, SDHB, SDHC, and SDHD, and 2 assembly factors, SDHAF1 and SDHAF2 (20).
Succinate dehydrogenase activity: The activity of
succinate dehydrogenase in MII oocytes (n=10 in each group) was detected by the method described by of Vivarelli (48).
Estimation of
Succinate Dehydrogenase (SDH) Activity in the Liver.
Histochemical stains showed normal myophosphorylase, phosphofructokinase and myoadenylate deaminase,
succinate dehydrogenase, nicotinamide adenine dinucleotide + hydrogen and cytochrome oxidase activity.
1965), and
succinate dehydrogenase (Hosseini et al.
About 70% paragangliomas are sporadic, 30% are hereditary, having identifiable germline mutations of
Succinate Dehydrogenase enzyme (SDH).