* Tacrine (Cognex[R]): Unlike donepezil, rivastigmine and galantamine, this drug prevents breakdown of acetylcholine in the body as well as the brain, which may help with earlier- and mid-stage Alzheimer cases.
Tacrine (Cognex) is used to prevent the breakdown of ACh and, thereby, improve cognitive function in AD patients.[20] Donepezil (Aricept) is another drug used to preserve available amounts of ACh, which facilitates cognitive functions.[20] These benefits support the notion that a deficiency in ACh causes the cognitive problems related to AD.
Since the drug's approval, the need for weekly liver function tests has likely made some physicians reluctant to prescribe Cognex (tacrine hydrochloride) for their patients with Alzheimer's disease.
CYP1A2 plays an important role in the metabolism of several clinically used drugs, including theophylline, clozapine and tacrine, and foodborne procarcinogens such as polycyclic aromatic hydrocarbons or imidazoquinoline derivatives (Faber et al.
A new drug called tacrine (which is sold under the brand name Cognex) slows deterioration, but only modestly, only in some patients, and only for six months or so.
One of the most innovative and often discussed pharmaceutical introductions in 1993 was tacrine HCI, Parke-Davis' treatment for mild to modedrate dementia resulting from Alzheimer's disease.
Huperzine A, like the drug tacrine (THA), prevents acetylcholinesterase from breaking down this essential chemical, thus raising levels of acetylcholine in the brain and improving memory.
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