The Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial (ONTARGET) compared an ACE inhibitor (ramipril 10 mg) with an ARB (telmisartan 80 mg) or with the combination of the two drugs in patients with a high cardiovascular risk.
The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET), a multiyear study of thousands of patients, addressed both of those questions.
Investigators analyzed data on 3,883 patients from 14 randomized, controlled trials that evaluated three commercially available fixed-dose combinations of hydrochiorothiazide and an angiotensin receptor blocker (ARB)--losartan, telmisartan, or valsartan, They calculated costeffectiveness using annual average wholesale prices and pooled estimates of blood pressure reductions.
It is unknown whether the polymorphism is associated with blood pressure (BP) response to telmisartan or amlodipine, two widely prescribed antihypertensive drugs.
He said since the middle of this year the dispensing of anti-hypertensive drugs, specifically Tablet Telmisartan 40 mg dan Tablet Telmisartan 80 mg, to patients was reduced from one month to two weeks.
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