thiamine pyrophosphate

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Noun1.thiamine pyrophosphate - a coenzyme important in respiration in the Krebs cycle
cocarboxylase
coenzyme - a small molecule (not a protein but sometimes a vitamin) essential for the activity of some enzymes
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References in periodicals archive
Thiamine is a component of thiamine pyrophosphate, which participates in oxidative decarboxylation of pyruvic acid and [alpha]-ketoglutaric acid.
EFFECTS OF DIETARY THIAMINE SUPPLEMENTATION ON PERFORMANCE, EGG QUALITY, AND ANTIOXIDANT-RELATED ENZYMES IN CHINESE EGG-LAYING DUCKS
Thiamine, in the form of thiamine pyrophosphate (TPP), becomes an essential cofactor in glycolysis and mitochondrial oxidative decarboxylation of carbohydrates for energy formation [1, 3].
Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient
The enzyme PDH requires cofactor thiamine pyrophosphate. Thus, in case of thiamine deficiency, lactate cannot be metabolized to pyruvate and accumulates in large amounts resulting in severe lactic acidosis.
The fatal booze!--triple acid-base disorder in a patient with alcohol intoxication
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