Reported FIX activity was measured using an activated partial
thromboplastin time assay performed at a central laboratory.
The most common adverse reactions reported in patients treated with ALUNBRIG at the recommended 180 mg dosing regimen were increased aspartate aminotransferase, hyperglycemia, hyperinsulinemia, anemia, increased creatine phosphokinase, nausea, increased lipase, decreased lymphocyte count, increased alanine aminotransferase, diarrhea, increased amylase, fatigue, cough, headache, increased alkaline phosphatase, hypophosphatemia, increased abnormal activated partial
thromboplastin time, rash, vomiting, dyspnea, hypertension, decreased blood cell count, myalgia, and peripheral neuropathy.
[6] This pathway can be analyzed by measuring activated partial
thromboplastin time (aPTT) [5] thereby measuring the functional activity of Factors IX, X, XI, and XII.
(2) The 3.8% sodium citrated plasma appears to alter the International Sensitivity Index (ISI) of some
thromboplastin times (3-5) but is still the preferred material for special platelet function tests.
However, her laboratory tests deserve some comments: there was a strong presence of LA according to the dilute Russell's viper venom time (DRWT), but the activated partial
thromboplastin time (APTT) was within the reference interval.
Initial coagulation parameters were recorded and included initial international normalized ratio, postreversal international normalized ratio, initial activated partial
thromboplastin time, postreversal activated partial
thromboplastin time, initial prothrombin time, and postreversal prothrombin time.
Suspecting neonatal Purpura Fulminans, laboratory investigations including complete blood count (CBC), Prothrombin time (PT), Activated Partial
Thromboplastin Time (APTT), Protein C, and Protein S were sent which showed following results:
The partial
thromboplastin time has been the gold standard for monitoring.
Prothrombin time and activated partial
thromboplastin time, albumin levels and alpha-1 antitrypsin value checked for liver failure were normal.
The reason cuts that result from blunt trauma don't bleed as much as wounds from sharp cuts is because the trauma stimulates the release of
Thromboplastin. This is a plasma protein that rapidly aids in blood coagulation.
Activated partial
thromboplastin time (aPTT) was prolonged at 47.7 seconds.