throm·bo·plas·tin

(thrŏm′bō-plăs′tĭn)

A complex of protein and phospholipids that is found in tissues and platelets and facilitates blood clotting by converting prothrombin to thrombin.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

thromboplastin

(ˌθrɒmbəʊˈplæstɪn)

(Biochemistry) any of a group of substances that are liberated from damaged blood platelets and other tissues and convert prothrombin to thrombin. Also called: thrombokinase

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

throm•bo•plas•tin

(ˌθrɒm bəˈplæs tɪn)

n.

a lipoprotein in the blood that converts prothrombin to thrombin.

Also called throm•bo•ki•nase (ˌθrɒm boʊˈkaɪ neɪs, -ˈkɪn eɪs)

[1910–15]

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

thromboplastin - an enzyme liberated from blood platelets that converts prothrombin into thrombin as blood starts to clot

factor III, thrombokinase

clotting factor, coagulation factor - any of the factors in the blood whose actions are essential for blood coagulation

Mentioned in

References in periodicals archive

Keywords: Tissue factor, Oxidised low density lipoprotein, Lectin-like oxidised LDL receptor, Beta (2)-Glycoprotein I.

Recombinant Domain V of beta (2)-Glycoprotein I Inhibits OxLDL-induced TF Expression in Macrophages

(5)- (7) Cigarette smoking exposure effects on hemostasis have been documented in decreased expression tissue factor pathway inhibitor and increased smokers plasma fibrinogen levels compared to non-smokers.

Effects of cigarette smoking on coagulation screening tests and platelet counts in a Sudanese male adults population

Pathogenesis of clotting mechanism in vein is tissue factor that leads to thrombin generation and activation of white cells.

Aspirin reduces Pre-Eclampsia by 24 %. Preterm birth by 14% and intrauterine growth retardation by 20%-Prof. Naela Tarique - Further studies needed to confirm benefit of Aspirin in prevention of Cataract the leading cause of blindness-Prof. Saeed

[3] Pancreatic cancer is associated with an increase in procoagulants such as tissue factor, thrombin, and fibrinogen.

Submassive pulmonary thromboembolism as a first sign of occult adenocarcinoma

Independent from bleeding, the physiopathology of intraabdominal adhesions following surgical operations is reported to be induced by fibrin clots due to fibrinogen activated by the tissue factor or more specifically, the "fibrin gel matrix" (7).

Are the skin scar characteristics and closure of the parietal peritoneum associated with pelvic adhesions?/Deri skari ozellikleri ile parietal peritonun kapatilmasi pelvik adhezyonlar ile iliskili mi?

Platelet count, leukocyte count, hemoglobin, d-dimer, tissue factor, soluble P-selectin, factor VIII, and prothrombin fragment F 1+2 are potential biomarkers that maybe predictive of vein thromboembolism in cancer [10-12].

Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma

A PT reagent consists of CaCl2 plus tissue factor protein and a phospholipid mixture, which together function as thromboplastin to activate factor VII and the extrinsic coagulation pathway.

Commentary

(2) Coagulation disorder: endothelium up-regulates the expression of tissue factor (TF), activates the exogenous coagulation pathway, and increases the release of von Willebrand factor from endothelial cells.

Sepsis and Intestinal Microvascular Endothelial Dysfunction

The rTEG test incorporates both tissue factor and kaolin to generate the conventional kaolin parameters as well as the TEG activated clotting time (ACT) parameter.

New-Generation Thromboelastography: Comprehensive Evaluation of Citrated and Heparinized Blood Sample Storage Effect on Clot-Forming Variables

Another study (4) states that the tendency to prothrombotic state is higher when the formation of monocyte tissue factor (TF) is increased, and prothrombin fragment [(F) 1+2] (a marker of thrombin generation in vivo) levels are elevated.

Association Between Soluble CD40 Ligand and Hypercholesterolemia in Children and Adolescents/Cocuk ve Adolesanlarda Soluble CD40 Ligandi ile Yuksek Kolesterol Duzeylerinin Iliskisi

Keywords: Sepsis, kidney, aqueous garlic extract, oxidative stress, tissue factor

Effect of an Aqueous Garlic Extract on Kidney Damage in an Experimental Model of Sepsis/Sulu Sarimsak Ekstresinin Deneysel Sepsis Modelinde Bobrek Hasari Uzerine Etkisi