A recent study of IVH incidence in infants receiving two tocolytic regimens found an increased incidence of grades 111 and IV IVH in infants whose mothers had received both magnesium and indomethacin versus those whose mothers had received magnesium alone (Ianucci, Besinger, Fisher, Gianopoulos, & Tomich, 1996).
In literature, the cases of the massive vulvar edema have been described associated with multiple pregnancy, diabetes, hypoproteinemia, preeclampsia, tocolytic therapy, vulvovaginitis, and severe anemia [1-4].
Conclusion: Nifedipine, as a tocolytic, is found to be more effective in pregnancy prolongation when compared with Glyceryl trinitrate but has frequent maternal adverse drug effects.
During the study period women with premature contractions received tocolytic drugs (hexoprenaline only until 2001, nifedipine or hexoprenaline from 2002 to 2008) for 48 hours to allow lung maturation with 24 mg of betamethasone.
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