tryp·sin·o·gen

(trĭp-sĭn′ə-jən)

The inactive precursor of trypsin, produced by the pancreas and converted to trypsin in the small intestine by enterokinase.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

trypsinogen

(trɪpˈsɪnədʒən)

(Biochemistry) the inactive precursor of trypsin that is converted to trypsin by the enzyme enterokinase

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

tryp•sin•o•gen

(trɪpˈsɪn ə dʒən, -ˌdʒɛn)

n.

a precursor of trypsin that is secreted by the pancreas and converted to trypsin in the small intestine.

[1885–90]

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

trypsinogen - inactive precursor of trypsin; a substance secreted by the pancreas and converted to active trypsin by enterokinase in the small intestine

trypsin - an enzyme of pancreatic origin; catalyzes the hydrolysis of proteins to smaller polypeptide units

Translations

tryp·sin·o·gen

n. tripsinógeno, sustancia inactiva segregada por el páncreas en el intestino convertida en tripsina.

English-Spanish Medical Dictionary © Farlex 2012

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References in periodicals archive

The granted patent issued by the USPTO now confers exclusive rights to the Company's lead product, PRP, by demonstrating that compositions comprising trypsinogen and chymotrypsinogen exhibit a synergistic ability to inhibit the growth of various cancer cell lines.

PROPANC BIOPHARMA GRANTED US PATENT FOR PRP

The remarkable achievement to identify and develop a suitable method to measure four key analytes from PRP, the two proenzymes, trypsinogen and chymotrypsinogen, as well as the activated enzymes, trypsin and chymotrypsin, is particularly significant due to the close structural similarity of each protein structure.

Propanc Biopharma Completes Development of Bio-analytical Assay Method to Quantify PRP's Active Ingredients in Preparation for First-In-Human Study

Immunoreactive trypsinogen (IRT) as a biomarker for cystic fibrosis: challenges in newborn dried blood spot screening.

The Incidence of Cystic Fibrosis in the Central Region of Anatolia in Turkey Between 2015 and 2016

Pancreatic trypsinogen is produced as an inactive precursor of the enzyme trypsin and recognized by antibodies.

Advances in the Diagnosis and Management of Cystic Fibrosis in the Genomic Era

Number Enzyme Accepted name Other names number 1 EC Yeast proteinase A Saccharopepsin 3.4.23.8 2 EC Rhizopus acid Rhizopuspepsin 3.4.23.9 proteinase 3 EC Endothia acid Endothiapepsin 3.4.23.10 proteinase 4 EC Retropepsin HIV aspartyl 3.4.23.16 protease, HIV proteinase, retroproteinase, HIV- 1 protease, HIV-2 protease 5 EC Aspergillopepsin I Proteinase, 3.4.23.18 Aspergillus acid protease, Aspergillus acid proteinase, Aspergillus aspartic proteinase, Aspergillus carboxyl proteinase, denapsin, proctase B, P, proteinase B, sumizyme AP, trypsinogen kinase, pepsin-type aspartic proteinase, carboxyl proteinase 6 EC Aspergillopepsin II Proteinase A, proctase 3.4.23.19 A, Aspergillus niger var.

The Role of Microbial Aspartic Protease Enzyme in Food and Beverage Industries

Newborn screening (NBS) for CF started as a pilot study in Colorado in 1980 [2] after the identification of elevated immunoreactive trypsinogen (IRT) in the dried blood spot of newborns with CF [3].

Newborn Screening Saves Lives but Cannot Replace the Need for Clinical Vigilance

The polymorphisms at PRSS1-PRSS2 rs10273739, which influence trypsinogen expression, and MORC4 rs12688220, which associate with atypical localization of cludin-2 in pancreatic acinar cells, are associated with acute pancreatitis [5], related recurrent acute pancreatitis, and chronic pancreatitis [3, 4].

The Polymorphisms at PRSS1-PRSS2 and MORC4 Loci and the Risk of Post-ERCP Pancreatitis

Prediction of the severity of acute pancreatitis on admission by urinary trypsinogen activation peptide: A meta-analysis World J Gastroenterol 2013; 19: 4607-4615.

Comparison of contrast-enhanced CT with diffusion -weighted MRI in the Evaluation of patients with acute biliary pancreatitis

In the normal state these enzymes are synthesized in pancreatic acinar cells as inactive pro-enzymes (such as trypsinogen) and are maintained in this state until activated by enterokinase upon entry into the gut lumen.

Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders

Serum C-reactive protein at 48 hours, urinary trypsinogen activation peptides within 12-24 hours of onset14, serum levels of interleukins 6 and 8 are the areas attracting latest interest to predict severity and prognosis15.

ACUTE PANCREATITIS WITH NORMAL AMYLASE AND LIPASE LEVELS

First, a blood spot is obtained in the first few days of life to measure immunoreactive trypsinogen (IRT).

Shining new light on newborn screening of cystic fibrosis in the province of Quebec

Bovine serum albumin (66kDa), ovoalbumin (45kDa), glyceraldehyde 3-phosphate dehydrogenase (36kDa), carbonic anhydrase (29kDa), trypsinogen (24kDa), trypsin inhibitor (20kDa) and lactoalbumin (14.2kDa) were used as molecular weight markers.

Trypsin from jumbo squid (Dosidicus gigas) hepatopancreas: purification and characterization/Tripsina del hepatopancreas de calamar gigante (Dosidicus gigas): purificacion y caracterizacion/Tripsina do hepatopancreas de lula gigante (Dosidicus gigas): purificacao e caracterizacao