"It's also good for premalignant epithelial targets such as actinic keratoses, actinic cheilitis, vulvar intraepithelial neoplasia, vaginal intraepithelial neoplasia, and oral leukoplakia," he said.
Chapters cover topics such as vulvar dystrophies, vulvar intraepithelial neoplasia and cancer, endometrial hyperplasia and cancer, adnexal mass, ovarian tumors of low malignant potential, and gestational trophoblastic disease.
Gardasil was 100% efficacious in reducing incidence of any grade of vulvar intraepithelial neoplasia or vaginal intraepithellal neoplasia related to the vaccine HPV types in studies of participants negative at baseline.
There are 2 main pathogenetic pathways for the development of precursors to invasive squamous cell carcinoma of the vulva (VSCC): human papilloma virus (HPV) related (classic or usual-type vulvar intraepithelial neoplasia, uVIN) and non-HPV-related (differentiated or simplex vulvar intraepithelial neoplasia, dVIN).
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