ZDV

abbr.

zidovudine

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

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Noun

ZDV - an antiviral drug (trade name Retrovir) used in the treatment of AIDS; adverse side effects include liver damage and suppression of the bone marrow

AZT, Retrovir, zidovudine

NRTI, nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs

Mentioned in

References in periodicals archive

Approximately 18% (n = 138) had no access to the antenatal component of the package and at least 10.4% (n = 95) had not received intrapartum IV ZDV. The vast majority of the newborns (95.3%) had access to infant formula (Table 2).

Cascade of access to interventions to prevent HIV mother to child transmission in the metropolitan area of Rio de Janeiro, Brazil

ZDV + ABC (n=6) TAMs or wild type No M184V or other ABC mutations ZDV + 3TC (n=4) M184V [right arrow] TAMs ABC + 3TC (n=6) M184V [right arrow] K65R and/or L74V Table 2: Factors that influence the decision to change a failing antiretroviral regimen in children.

Antiretroviral drug resistance in HIV-infected children: implications for long-term treatment

Maternal ZDV use prenatally and/or during L&D increased significantly from 27% in 1993 to 85% in 2000 (p<0.01; chi square for linear trends) (Table 1), and peaked at 95% in 1998.

Progress toward elimination of perinatal HIV infection -- Michigan, 1993-2000

(7) In adults, switching from d4T to ABC was superior to switching from d4T to ZDV. (8) In older children, once-daily use of ABC has also been shown to be effective, thereby facilitating adherence and improving patient satisfaction, particularly when all drugs are given once daily.

Abacavir: its use and hypersensitivity

Almost half of the patients who presented TOX-MOD were on ZDV + 3TC + EFV.

Incidence rate of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity during the first year of treatment stratified by age

(3) Since mid-2003, ZDV was added from 34 weeks' gestation for the mother and for a week for the neonate.

A window into a public programme for prevention of mother-to-child transmission of HIV: Evidence from a prospective clinical trial

Data about HIV testing, ZDV receipt, and prenatal care were collected from medical records for the mother (prenatal and labor and delivery) and the infant (newborn and pediatric HIV clinic).

Success in Implementing Public Health Service Guidelines to Reduce Perinatal Transmission of HIV - Louisiana, Michigan, New Jersey, and South Carolina, 1993, 1995, and 1996

In 1994, a clinical trial in the United States and France demonstrated that zidovudine (ZDV) administered orally five times a day to HIV-infected pregnant women starting at 14-34 weeks' gestation, intravenously during labor, and orally to their newborns for 6 weeks reduced the risk for perinatal HIV transmission by two thirds (2).

Administration of zidovudine during late pregnancy and delivery to prevent perinatal HIV transmission - Thailand, 1996-1998

Nucleoside analogs are strongly associated with mitochondrial toxicity, and zidovudine (ZDV) causes bone marrow suppression.

Aging with HIV: a practical review

(11) Zidovudine (ZDV) from 28 weeks' gestation, with a single dose of NVP to the mother at delivery and ZDV and NVP to the infant after birth, can reduce transmission in non-breastfeeding populations to 2%.

Enhancing PMTCT programmes through psychosocial support and empowerment of women: the mothers2mothers model of care

In 1994, clinical trials demonstrated a two-thirds reduction in the risk for perinatal transmission associated with treatment of HIV-infected pregnant women and their infants with zidovudine (ZDV) therapy (3).

Update: perinatally acquired HIV/AIDS - United States, 1997