Pratico's team gave
Zyflo (zileuton) to mice genetically engineered to develop tau tangles .
To this day, zileuton (1) (
Zyflo) remains the only 5-LO inhibitor approved for use by clinicians to help alleviate symptoms associated with asthma [11, 12].
Medications commonly used to treat asthma include corticosteroids (inhaled and oral), leukotriene antagonists (Singulair, Accolate, and
Zyflo), theophylline, bronchodilators (both short- and long-acting), and xolair (Omalizumab).
If these cognitive symptoms bother you, speak to your health care provider, who may adjust dosage levels or suggest alternative drugs such as leukotriene modifiers (Singulair;
Zyflo), mast cell stabilizers (Crolom; Nasalcrom; Tilade), or the antibody omalizumab (Xolair), which prevents the release of inflammatory chemicals that narrow the airways.
* Leukotriene inhibitors include zileuton (
Zyflo; Category C), montelukast (Singulair; Category B), and zafirlukast (Accolate; Category B).
(Cary NC) alleging that the company's promotional materials withheld information about the risks of its asthma drug
Zyflo CR.
There are two other members of this class of medications, zafirlukast (Accolate) and zileuton (
Zyflo).
The oral medications that patients in the study were using were the leukotriene modifiers zafirlukast (Accolate), montelukast (Singulair), and zileuton (
Zyflo).
The drugs affected by the FDA announcement include montelukast (Singulair), zafirlukast (Accolate) and zieuton (
Zyflo and
Zyflo CR).
The agency said the reported neuropsychiatric events included cases of agitation, aggression, anxiety, dream abnormalities and hallucinations, depression, insomnia, irritability, restlessness, suicidal ideation and behavior, and tremor in patients using montelukast (Singulair), zafirlukast (Accolate), and zileuton (
Zyflo,
Zyflo CR).
The FDA, which issued the call in mid June, said the reported neuropsychiatric events included cases of agitation, aggression, anxiety, dream abnormalities and hallucinations, depression, insomnia, irritability, restlessness, suicidal ideation and behavior, and tremor in patients using montelukast (Singulair), zafirlukast (Accolate), and zileuton (
Zyflo,
Zyflo CR).
Zileuto - Zileuton, also known as
Zyflo CR, extended release, is an orally active inhibitor of 5-LO.