ac·e·to·a·ce·tic acid

(ăs′ĭ-tō-ə-sē′tĭk, ə-sē′tō-)

An organic acid, C₄H₆O₃, that is one of the ketone bodies that accumulate in the blood and urine when fat is being metabolized.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

a•ce•to•a•ce′tic ac′id

(əˌsi toʊ əˈsi tɪk, -əˈsɛt ɪk, ˌæs ɪ toʊ-)
n.

a colorless, oily liquid, C₄H₆O₃, soluble in water, alcohol, and ether: used in synthetic organic chemistry.

[1895–1900]

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

acetoacetic acid - unstable acid found in abnormal amounts in the blood and urine in some cases of impaired metabolism (as diabetes mellitus or starvation)

acetone body, ketone body - a ketone that is an intermediate product of the breakdown of fats in the body; any of three compounds (acetoacetic acid, acetone, and/or beta-hydroxybutyric acid) found in excess in blood and urine of persons with metabolic disorders

Translations

Acetessigsäure

Mentioned in

References in periodicals archive

Another study showed that acetoacetate and BHB were affected by increasing transamination of glutamate to aspartate and conversion to gamma-aminobutyric acid (10).

The Effect of Ketogenic Diet Treatment in Drug-resistant Epilepsies of Childhood/Cocukluk Cagi Direncli Epilepsilerinde Ketojenik Diyet Uygulamalarinin Etkisi

As can be seen, 15 (glucose, lactate, pyruvate, acetoacetate, BHBA, fumaric acid, citric acid, choline, glycine, proline, isoleucine, leucine, urea, creatinine, and orotic acid) of the 33 potential biomarkers were also discovered in blood or milk in our previous studies [4,5].

Liver metabolic perturbations of heat-stressed lactating dairy cows

This group had higher levels of acetoacetate and acetate than the NGT group (Figure 4) and the highest level of 3-HIB; no differences in BCAAs were found (data not shown).

Higher Concentrations of BCAAs and 3-HIB Are Associated with Insulin Resistance in the Transition from Gestational Diabetes to Type 2 Diabetes

It is metabolized sequentially into 3-hydroxy-3-methylglutaryl-CoA and then into acetoacetate (Figure 1) [9].

Pregnancy Ketonemia and Development of the Fetal Central Nervous System

The conventional methods employed for the synthesis of substituted isoxazole-5(4H)ones, include cyclization of O-propioloyl oximes [27], reaction of ethyl acetoacetate and hydroxylamine hydrochloride followed by the Knoevenagel condensation with aromatic aldehydes in two steps [28-30], condensation of substituted benzaldoximes and 1,3-dicarbonyl compounds [31], and reaction of [beta]-oxoesters with hydroxylamine and sodium hydroxide with subsequent addition of aqueous HCl followed by heating [32].

KI-Mediated Three-component Reaction of Hydroxylamine Hydrochloride with Aryl/Heteroaryl Aldehydes and Two [beta]-Oxoesters

Peng et al., "Acetoacetate induces hepatocytes apoptosis by the ROS-mediated MAPKs pathway in ketotic cows," Journal of Cellular Physiology, vol.

Immune Regulation of RAW264.7 Cells In Vitro by Flavonoids from Astragalus complanatus via Activating the NF-[kappa]B Signalling Pathway

Ethyl acetoacetate: A potential bio-based diluent for improving the cold flow properties of biodiesel from waste cooking oil.

Performance And Emission Studies On Cashewnut Shell Liquid Bio-Oil Fuelled Diesel Engine With Acetone As Additive

Ketones (primarily beta-hydroxybutyrate and acetoacetate) are formed in the liver from the newly released fatty acids, and released into the circulation, including into the brain during times of decreased glucose availability--a state characteristic of Alzheimer's disease.

Fueling the Alzheimer's brain, upping cognition with fat

Although urine ketone dipsticks tests routinely measure urinary acetoacetate, they do not detect the ketone predominant in HG, which is [beta]-hydoxybutyric acid ([beta]-HBA).

Diagnosis of Hyperemesis Gravidarum in Patients with Pregnancy-Induced Vomiting Using a Point-of-Care Ketone Blood Test

Allelochemical ethyl 2-methyl acetoacetate (EMA) induces oxidative damage and antioxidant responses in Phaeodactylum tricornutum.

RHIZOTOXICITY OF THE INVASIVE SPECIES MELIA AZEDARACH: IMPLICATION OF PHENOLS ON ITS HERBICIDE POTENTIAL

Ketone bodies are three small water-soluble molecules of acetoacetate, 3-hydroxybutyrate, and acetone.

Diets for Patients with Amyotrophic Lateral Sclerosis: Pay Attention to Nutritional Intervention

The pKa of an acetoacetate C-H is around 10.7; for a malonate, it is even higher (>13).

Isocyanat-free michael addition cured aliphatic topcoats