a·cet·y·late

(ə-sĕt′l-āt′)

tr.v. a·cet·y·lat·ed, a·cet·y·lat·ing, a·cet·y·lates

To bring an acetyl group into (an organic molecule).

a·cet′y·la′tion n.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

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Noun

acetylation - the process of introducing an acetyl group into a compound; "the acetylation of cyclooxygenase-2 by aspirin"

acylation - the process of introducing an acyl group into a compound

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References in periodicals archive

KDAc Therapeutics is a biotechnology company founded on technologies licensed from the Broad Institute of MIT and Harvard to translate discoveries in lysine acetylation and epigenetic regulation into novel treatments for cancer patients.

OnKure Executes License and Option Agreement with KDAc Therapeutics

Redox imbalance and increased protein acetylation was found in heart tissue from mice and human patients in advanced staged heart failure.

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Unlike the other HDAC family members, HDAC6 is mainly located in the cytoplasm and has little effect on DNA histone acetylation. CS3003 has the potential to be combined with PD-(L)1 antibody drugs in solid tumours to expand the clinical efficacy of immunological checkpoint inhibitors.

CStone passes NMPA IND approval in China for the HDAC6 inhibitor CS3003

The main epigenetic mechanisms that in mammalian cells contribute to the regulation of gene expression include DNA methylation, histone post-translational modifications (such as methylation, acetylation, phosphorylation), and ubiquitination (21).

Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension

Although it didn't reduce aortic inflammation, adalimumab had a positive effect on glycoprotein acetylation, a marker of inflammation and subclinical cardiovascular disease in psoriasis.

Adalimumab strikes out for aortic inflammation in psoriasis study

To date, the most commonly epigenetic changes include DNA methylation and histone modifications, such as methylation and acetylation at lysine residues.

Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer

[36] to demonstrate for the first time a role for histone acetylation in the early tagging of OFC in young animals.

Environmental Enrichment Induces Changes in Long-Term Memory for Social Transmission of Food Preference in Aged Mice through a Mechanism Associated with Epigenetic Processes

Acetylation and deacetylation of histones are controlled by histone acetyltransferases (HAT) and histone deacetylases (HDACs), respectively.

Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis

Interestingly, [N.sup.6]-formyllysine residues were found to be refractory to acetylation in cells and in vitro (Edrissi et al.

Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells

Protein acetylation is a common posttranslational modification which may rank second to protein phosphorylation [10].

Histone acetyltransferase inhibitors antagonize AMP-activated protein kinase in postmortem glycolysis