a·chon·dro·pla·sia

(ā-kŏn′drō-plā′zhə)

Improper development of cartilage at the ends of the long bones, resulting in a form of congenital dwarfism.

a·chon′dro·plas′tic (-plăs′tĭk) adj.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

achondroplasia

(eɪˌkɒndrəʊˈpleɪzɪə)

(Pathology) a skeletal disorder, characterized by failure of normal conversion of cartilage into bone, that begins during fetal life and results in dwarfism

[C20: New Latin; see a-¹, chondro-, -plasia]

achondroplastic adj

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

a•chon•dro•pla•sia

(eɪˌkɒn drəˈpleɪ ʒə, -ʒi ə)

n.

a defect of fetal bone development, resulting in a type of dwarfism characterized by a large head and short limbs.

[1890–95; a-⁶ + Greek chóndro(s) cartilage + -plasia]

a•chon`dro•plas′tic (-ˈplæs tɪk) adj.

achondroplasia

An inherited condition resulting in short stature. There is defective cartilage growth and defective ability to form bones.

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

achondroplasia - an inherited skeletal disorder beginning before birth; cartilage is converted to bone resulting in dwarfism

achondroplasty, chondrodystrophy, osteosclerosis congenita

congenital disease, genetic abnormality, genetic defect, genetic disease, genetic disorder, hereditary condition, hereditary disease, inherited disease, inherited disorder - a disease or disorder that is inherited genetically

Translations

Achondroplasie

achondroplasie

a·chon·dro·pla·si·a

[MIM*100800 *134934]

n. acondroplasia, deformidad ósea de nacimiento; enanismo.

English-Spanish Medical Dictionary © Farlex 2012

achondroplasia

n acondroplasia

Mentioned in

References in periodicals archive

ACHONDROPLASIA: A male patient 45 years of age with short stature reported for the complaint of stunted growth and difficulty of using his left hand.

Achondroplasia and Ellis Van Creveld syndrome

"I am just an ordinary Sri Lankan girl who has achondroplasia, but I love my life.

The little girl who dreams big

ALASTAIR and Claire McLean remember the emotions they felt when son Hamish was born with achondroplasia, or dwarfism as it's better known.

BORN DIFFERENT.. BUT STILL A REAL BOY

Ascendis Pharma announced the filing of an investigational new drug, or IND, application with the FDA to initiate the ACcomplisH Trial, a global phase 2 trial designed to evaluate the safety and efficacy of TransCon CNP in children with achondroplasia. TransCon CNP is a long-acting prodrug of C-type natriuretic peptide, or CNP, in development for children with achondroplasia.

Ascendis Pharma files IND application to initiate ACcomplisH trial

Release date- 18062019 - Researchers at Johns Hopkins Medicine, the Murdoch Children's Research Institute in Australia and seven other medical institutions report that an experimental drug called vosoritide, which interferes with certain proteins that block bone growth, allowed the average annual growth rate to increase in a study of 35 children and teenagers with achondroplasia, a form of dwarfism.

Johns Hopkins University - Study Shows Experimental Drug Can Encourage Bone Growth in Children with Dwarfism

And to top it off Nevaeh, who has a form of dwarfism called Achondroplasia, met Paralympic legend Ellie Simmonds at the event.

Golden girl comes out on top at Dwarf Sports Association championships; Nevaeh Mason-Grant wins host of medals at the event at Birmingham's Alexandra Stadium

United States-based Pfizer has signed a definitive agreement to acquire all the shares of Therachon Holding AG, a privately-held clinical-stage biotechnology company focused on rare diseases, with assets in development for the treatment of achondroplasia and short bowel syndrome, it was reported yesterday.

Pfizer signs definitive agreement to acquire all Therachon Holding shares

Under the terms of the agreement, Pfizer will acquire Therachon for USD 340m upfront with an additional USD 470m in additional payments contingent on the achievement of key milestones in the development and commercialisation of TA-46 for the treatment of achondroplasia, a genetic condition and the most common form of short-limbed dwarfism.

Pfizer Acquires Swiss Biotech Therachon for USD 810m

The literature data on the use of growth hormone in skeletal dysplasias are scarce except for in achondroplasia, and usually short-term treatment results have been reported (9).

Evaluation of Efficacy of Long-term Growth Hormone Therapy in Patients with Hypochondroplasia

(7) Infantile Tay-Sachs disease, for example, uncontroversially reduces well-being, while many have argued that deafness and achondroplasia (the most common type of dwarfism) do not reduce well-being at all.

WELL-BEING, OPPORTUNITY, AND SELECTING FOR DISABILITY