Finally, an in vivo animal model showed that
adoptively transferred cytotoxic T cells persisted in mice following administration of CD45 targeted lymphodepletion and were able to control tumor cells compared to untreated mice.
We randomly assigned the stimulus conditions, and
adoptively changed the imposed gap duration of the adjustable stimulus, based on the participants' response.
Similarly, immunodeficient mice
adoptively transferred with [CD4.sup.+]IL-[21.sup.-/-] T cells develop less severe colitis [60, 61], and mice treated in a prophylactic setup with a neutralizing IL-21R/Fc fusion protein or anti-IL-21 mAb are protected from both DSS and TNBS-induced colitis [31, 58, 59].
Bollard et al., "Enhancing the in vivo expansion of
adoptively transferred EBV- Specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients," Blood, vol.
To further confirm the role of Id1 in BMP6-induced BMMSC immunosuppressive function impairment, we
adoptively transferred OT-II T cells plus BMMSCs treated with or without BMP6 or Id1 siRNA to CD45.1 transgenic C57BL/6 mice.
Inhibition of pro-inflammatory cytokine generation by CTLA4-Ig in the skin and colon of mice
adoptively transplanted with CD45RBhi CD4+ T cells correlates with suppression of psoriasis and colitis.
Moreover, HBV immunity can be
adoptively transferred in allogeneic bone marrow transplants.