Adrenochrome and tranexamic acid (both 1.6% each) were the least prescribed drugs in this group (Figure 8).
infusion of
adrenochrome in rats," British Journal of Experimental Pathology, vol.
subcutaneously, Intacal (a) 10 ml intramuscularly,
Adrenochrome monosemicarbazone 5 ml intramuscularly for one week.
Walsh appreciated Hoffer's work demonstrating neurochemical abnormalities in "
adrenochrome," an older term for a dopamine and norepinephrine metabolite.
Adrenaline rapidly undergoes auto-oxidation at pH 10, 7 producing
adrenochrome, which is a pink colored product that can be measured at 480 nm with UV/VIS spectrophotometry.
The method is based on inhibition the enzymes of autooxidation of adrenaline in the alkaline environment (pH 10.2) and formation of
adrenochrome, registered on change of optical density at 480 nm.
One unit of Superoxide Dismutase activity is the amount of the enzyme required for 50% inhibition of the oxidation of epinephrine to
adrenochrome at 480 nm per min.
Catecholamine-induced myocardial cell damage: catecholamines or
adrenochrome. J Mol Cell Cardiol 1985; 17:349-59.