Olechowski, Bradley Kerr, PhD, and colleagues (University of Alberta, Edmonton) studied "
allodynia" in mice with MS-like EAE.
People who suffer from migraines may also experience cutaneous
allodynia, a condition in which you feel pain on your scalp from a source that should not cause pain, such as a single strand of hair.
It is characterized by spontaneous burning pain and/or ongoing pain with accompanying hyperalgesia and
allodynia (1-2).
(6,8,9) In rat models, ketamine was shown to effectively lessen the hyperalgesia (increased sensitivity to painful stimuli),
allodynia (pain sensation from nonnoxious stimuli), and spontaneous pain associated with neuropathic pain.
The change that occurred in injured afferents is the sensitization of the nociceptive afferents that account for the characteristic symptoms of neuropathic pain such as
allodynia, hyperalgesia and ongoing pain (3).
CRPS-I is characterized by the following features: pain, which may take the form of spontaneous pain, hyperalgesia and
allodynia; movement disorders, both active and passive; abnormal sympathetic regulation in the form of blood flow and sweating abnormalities; edema and trophic changes to the involved tissues (Table 1).
The two self-examination items include
allodynia and numbness.
Researchers who studied 16,500 people, found that 68 per cent with chronic daily migraines and 63 per cent with irregular migraines had painful skin -
allodynia.
The presence and type of mechanical
allodynia (dynamic and static) was assessed.
Symptoms can include burning, searing, or stabbing pain; foreign body sensation, often as if there is a golf ball or grapefruit in the rectum, vagina, or perineum;
allodynia; pain restricted to the pudendal nerve territory: pain triggered by sitting and often relieved by sitting on a toilet seat, standing, or lying down; associated motor, sensory, or autonomic dysfunction; and swelling and discoloration of the genital area.
Many sufferers also experience pain from what is known as additional
allodynia -- pain caused by normally nonpainful stimuli like ripped clothing or light touch.