allograft - tissue or organ transplanted from a donor of the same species but different genetic makeup; recipient's immune system must be suppressed to prevent rejection of the graft
Thus, the objective of the treatment is to optimize the immunosuppressive dose in order to eradicate the virus while preventing allograft rejection; in some cases, antiviral therapies can be provided.
29 patients received a heart transplantation with complications including allograft rejection leading to re-transplant, muscle weakness and respiratory failure that required mechanical ventilatory support.
According to Natera, its organ transplant rejection assay is designed to detect active allograft rejection in patients who have undergone kidney transplantation.
TIM-3 is a type I membrane protein preferentially expressed on terminally differentiated Th1 cells, which seems to be central in the mechanisms of allograft rejection (15).
Moreover, due to the progression of allograft immunology, some new types of immunosuppressive agents and therapy are used and that have prevented or reversed acute allograft rejection effectively in the past 20 years, which lead to the short-term (1-year) allograft survival time of 88-95% [1].
Sensitization with donor-specific antibodies (DSA) to Human Leukocyte Antigen (HLA) has been shown to increase the risk of accelerated solid organ allograft rejection and loss [1].
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