angioedema - recurrent large circumscribed areas of subcutaneous edema; onset is sudden and it disappears within 24 hours; seen mainly in young women, often as an allergic reaction to food or drugs
PPD is an allergen as declared by the American Centers for Disease Control and Prevention that can induce renal, hepatic, and cardiac injury, angioneurotic edema, and delayed hypersensitivity.
In hereditary angioneurotic edema, activation of the classical complement pathway, caused by the deficiency of C1-esterase inhibitor, induces laryngeal edema, and androgens have been used for treatment in this disease [15].
For example, to evaluate shellfish, latex, or peanut allergy, one needs a patient with a known history of angioneurotic edema. Once a trend of indicator drops evidence on an unknown point on several known cases, then I become comfortable from the findings but continue to track the point for years with desktop notes.
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