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"In determining whether anticholinergic drug exposure has a causal role in clinical dementia in Parkinson disease, future studies may take a clinical trial approach, in which high-potency anticholinergic medications are replaced with lower-potency alternatives, and the change in cognitive testing and cognitive trajectory are measured," Dr.

Concurrent 'never event' prescribing may worsen Parkinson's

SAN DIEGO -- A topical anticholinergic drug, glycopyrronium tosylate, was as safe and effective for treating hyperhidrosis in children 9-16 years old as it was in adults in two phase 3 trials that included 25 treated children, raising the prospect it could become the first drug to gain Food and Drug Administration approval for treating pediatric hyperhidrosis.

Topical anticholinergic drug improved hyperhidrosis in children

Overall, 14,453 cases (35%) and 86,403 controls (30%) were prescribed at least one anticholinergic drug with an ACB score of 3 (definite anticholinergic activity) during the exposure period.

Anticholinergics' link to dementia calls for vigilance

The researchers found that 35 percent of cases and 30 percent of controls were prescribed at least one anticholinergic drug during the study period.

Certain Anticholinergic Drugs Appear to Raise Dementia Risk; Dementia link seen with antidepressant, urological, and anti-Parkinson's drugs

Penehyclidine hydrochloride (PHC) is a new anticholinergic drug derived from hyoscyamine, which is an anticholinergic agent with a high degree of selectivity for [M.sub.1] and [M.sub.3] receptor subtypes (12).

Effect of penehyclidine hydrochloride on [beta]-arrestin-1 expression in lipopolysaccharide-induced human pulmonary microvascular endothelial cells

Patients were eligible for the study if they demonstrated 8 or more voids per day on a 3-day bladder diary (whether or not they had a history of previous anticholinergic drug use).

Pelvic floor dysfunction

Which anticholinergic drug for overactive bladder symptoms in adults.

A review of Anticholinergic medications for overactive bladder symptoms

Procyclidine is an anticholinergic drug principally used for the treatment of Drug-induced Parkinsonism, Parkinson disease and others.

Suspected drug peddler on trial in UAE

A longitudinal cohort study found that patients taking anticholinergic drugs had an 80% prevalence of MCI, compared with a 35% prevalence in a matched population of patients not using these drugs; yet Alzheimer's disease hadn't increased among the anticholinergic drug users at 8-year follow-up.

Do patients at high risk of Alzheimer's disease benefit from early treatment?