As a result, only two plants have been reported to exhibit more than 90% of antiinflammatory activity using the nitric oxide inhibition assay, which were Melicope ptelefolia (Tenggek burung) and Portulaca oleracea (Gelang pasir) with the values of 95.00% and 94.80% at 250 [micro]g/ml, respectively [13].
FPR2, also known as the lipoxin A4 receptor (ALX), belongs to the Gi-protein coupled receptor (GiPCR) family and is activated by lipoxin A4, Annexin A1, and Annexin A1-derived peptides or by the acute phase reactant serum amyloid A resulting in potent antiinflammatory effects [9, 10].
The current study was designed to explore the antinociceptive, antiinflammatory and antipyretic activity of pistagremic acid (PA), isolated from Pistacia integerima bark in various animal paradigms.
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