High-dose chemotherapy to kill the cancer cells extirpates the bone marrow where blood cells are produced, producing aplasia and crippling the patient's immune system.
Pathological examinations of the testicular biopsy specimens revealed hypospermatogenesis, maturation arrest and germ cell aplasia in 34.4%, 31.2% and 34.4% of patients, respectively.
Trials have also reported development of serious infections, low blood cell counts, immunosuppression and B-cell aplasia. Therefore, these toxicities must be promptly reported as they may require immediate medical attention from the cancer care team and if overlooked may even result in death.
Following the second cycle, the patient experienced a four-month period of hematologic aplasia, which postponed the allogeneic stemcell transplant (allo-HSCT).
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