aux·o·troph·ic

(ôk′sə-trŏf′ĭk, -trō′fĭk)

adj.

Requiring one or more specific substances for growth and metabolism that the parental organism was able to synthesize on its own. Used with respect to organisms, such as strains of bacteria, algae, or fungi, that can no longer synthesize certain growth factors because of mutational changes.

[Greek auxein, to increase; see auxin + -trophic.]

aux·ot′ro·phy (ôk-sŏt′rə-fē) n.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

auxotrophy

(ˈɔːksəʊˌtrɒfɪ)

the inability to synthesize particular growth factors, due to mutational changes

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

References in periodicals archive

Murray, "Amino acid auxotrophy as a system of immunological control nodes," Nature Immunology, vol.

Determination of Free Amino Acids in Three Species of Duckweed (Lemnaceae)

Jacobs Jr., "NAD+ auxotrophy is bacteriocidal for the tubercle bacilli," Molecular Microbiology, vol.

Using Reduced Inoculum Densities of Mycobacterium tuberculosis in MGIT Pyrazinamide Susceptibility Testing to Prevent False-Resistant Results and Improve Accuracy: A Multicenter Evaluation

fumigatus mutants that exhibit auxotrophy for the three aromatic amino acids are impossible to obtain.

Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi

Gilsdorf, "Histidine auxotrophy in commensal and disease-causing nontypeable Haemophilus influenzae," Journal of Bacteriology, vol.

Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1

Ascorate abolishes auxotrophy caused by the lack of superoxide dismutase in Saccharomyces Cervesiae.

Yeast cells as antioxidant-producing probiotics: can they emulate vitamin E on in-vitro protection of human spermatozoa against oxidative stress?

There is some evidence that genetic safeguards, such as engineered auxotrophy, "kill switches", barriers to gene flow, and "genetic firewalls" can be built into organisms that are constructed using synthetic biology, (194) but there was no discussion in Oversight about how the use of genetic safeguards could be furthered by minimizing the regulation of sNA manufacturing in Canada.

The regulation of synthetic nucleic acids under the Human Pathogens and Toxins Act