az·a·thi·o·prine

(ăz′ə-thī′ə-prēn′)

An immunosuppressive agent used to prevent organ rejection in kidney transplant recipients and to treat severe rheumatoid arthritis.

[Probably from az(o)- + thio- + p(u)rine.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

azathioprine

(ˌæzəˈθaɪəˌpriːn)

(Pharmacology) a synthetic drug that suppresses the normal immune responses of the body and is administered orally during and after organ transplantation and also in certain types of autoimmune disease. Formula: C9H7N7O2S

[C20: from aza- + thio- + p(u)rine]

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

azathioprine - an immunosuppressive drug (trade name Imuran) used to prevent rejection of a transplanted organ

Imuran

medicament, medication, medicinal drug, medicine - (medicine) something that treats or prevents or alleviates the symptoms of disease

Translations

azathioprine

n azatioprina

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References in periodicals archive

Prednisone, azathioprine, and mycophenolate carried higher risks of serious infections at 6 months than methotrexate or cyclosporine, the authors said.

6-month infection risk lowest for cyclosporine, methotrexate

Azathioprine (AZA) (Immuran, GlaxoSmithKline, Middlesex, UK) was started at a dose of 2-2.5 mg/kg/d at the time of diagnosis or as the maintenance therapy during evaluation for a dose reduction of steroids at 4, 8, or 12 weeks.

Efficacy and safety of long-term thiopurine maintenance treatment for ulcerative colitis in Turkey: A single-center experience

The label update was based on data from a Roche-supported study by the French Vasculitis Study Group showing that treatment with the rituximab regimen resulted in fewer major relapses by month 28 compared to treatment with azathioprine. The observed safety profile was consistent with that previously observed in this patient population.

Roche reports FDA approves label update for Genentech's Rituxan

Following pulse therapy, 64 mg oral prednisolone and 150 mg (50 mg 3 times daily) azathioprine were co-administered.

Intravitreal Aflibercept as an Adjunct to Systemic Therapy in a Case of Choroidal Neovascular Membrane Associated with Sympathetic Ophthalmia

Azathioprine (AZA) still corresponds to the mainstay maintenance therapy in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (1, 2).

Azathioprine-induced interstitial nephritis in an anti-neutrophil cytoplasmic antibody (ANCA) myeloperoxidase (MPO) vasculitis patient

At symptom onset, she had received infliximab and azathioprine for >5 years and reported eating undercooked meat; she had not traveled abroad.

Chronic Genotype 3 Hepatitis E in Pregnant Woman Receiving Infliximab and Azathioprine

Azathioprine is an immunosuppressant used in the treatment of various autoimmune conditions, including myasthenia gravis.

Drug Hypersensitivity due to Azathioprine with Elevated Procalcitonin

Thiopurines, azathioprine (AZA), and 6-mercaptopurine (6MP) have been considered the reference maintenance treatment for patients with steroid-dependent and steroid-refractory moderate-to-severe UC for many years and are recommended as the first line immunosuppressive therapy by major guidelines [1, 5].

Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study

Immunomodulators including azathioprine, calcineurin inhibitors, and cyclosporine have been tried with mixed success [8, 16, 17].

Cronkhite-Canada Syndrome: Sustained Clinical Response with Anti-TNF Therapy

1 mg/kg/day oral corticosteroid, 25 mg/day azathioprine, warfarin tailored to international normalized ratio target, 3 tablets/day acetazolamide and 1 tablet/day potassium were started for the patient.

Neuro-Behcet Disease Presenting with Sinus Venous Thrombosis: Case Report/Sinus Ven Trombozu ile Prezente Olan Noro-Behget Hastaligi: Olgu Sunumu