These materials combine traditional wound dressings such as hydrogels or foams with antimicrobial compounds such as betaine, silver, chitin, or polyhexamethylene
biguanide.
One such pharmacologic maneuver that gained popularity lately is add-on use of metformin, a
biguanide oral hypoglycemic agent, which is also used in polycystic ovary disease.
We also use a
biguanide sanitation system (an alternative to chlorine), and change out the water completely every 3 to 4 months.
In this trial, Imeglimin is administrated as a monotherapy or combination therapy to over 700 patients with existing hypoglycemic agents, including a DPP4 inhibitor, SGLT2 inhibitor,
biguanide, sulphonylurea and GLP1 receptor agonist.
Biguanide and Sulphonyl urea were the most commonly prescribed OADs.
The PHMB Foam Dressing is a polyurethane foam impregnated with Polyhexamethylene
Biguanide (PHMB) that is indicated for use in the management of various chronic and post-surgical wounds including pressure sores, diabetic ulcers and burns.
They are pH-balanced, fragrance-free and free from alcohol, parabens, DMDM hydantoin (formaldehyde), propylene glycol and butylene glycol, ethanolamines (DEA, TEA, MEA), polyaminopropyl
biguanide (PHMB), SLS, latex, and harsh chemicals.
Critical colonization and infection are significant problems for EB patients and are ideally managed with topical antimicrobials such as hydrogen peroxide cream, enzymatic antimicrobials, polyhexamethylene
biguanide, and medical grade honey.
The patient was admitted to the hospital and was administered hourly topical treatments of polyhexamethylene
biguanide eye drops, hexamidine, and 1% atropine.
In the present study, we tested three different contact lens disinfecting solutions, of which Biotrue chemically contains polyaminopropyl
biguanide (0.00013%) and polyquaternium (0.0001%), Opti-Free Replenish contains polyquaternium/Polyquad (0.001%) and myristamidopropyl dimethylamine/Aldox (0.0005%), and Aquasoft contains polyhexamide.
Metformin is a
biguanide that reduces hepatic glucose production, increases glucose uptake by peripheral tissues, and activates AMP-dependent protein kinase (AMPK).