He presented a pooled analysis of one 16-week and four 8-week clinical trials in which 772 patients with active Crohn's disease were randomized to budesonide 9 mg/day prednisolone 40 mg/day with a taper, or placebo.
A study reported in the June 9 issue of the Journal of the American Medical Association (JAMA) found that patients thus treated in an emergency department and then given budesonide inhalers with oral prednisone for the next 21 days did better than those discharged on oral prednisone alone.
Bateman, M.D., from the University of Cape Town in South Africa, and colleagues randomized patients aged 12 years or older with mild asthma who were eligible for regular inhaled glucocorticoids to receive twice-daily placebo plus budesonide-formoterol used as needed (2,089 patients) or budesonide maintenance therapy plus terbutaline as needed (2,087 patients).
After excluding the patients who needed emergent and negative bronchoscopies, the remaining clinically stable 84 patients were compared for the effects of preoperative administration of nebulized albuterol and budesonide combination on bronchoscopy complications.
The risk/benefit profile of inhaled budesonide to prevent bronchopulmonary dysplasia remains uncertain, given that the treatment effects on the composite outcome in this study moved in opposite directions.
A double-blind, placebo-controlled RCT, CAMP studied the linear growth of 1041 children with mild-to-moderate persistent asthma who were divided into 3 treatment groups: One group received 200 mcg inhaled budesonide twice daily; a second group received 8 mg inhaled nedocromil twice daily; and a third group received placebo.
SAN FRANCISCO -- Using inhaled budesonide daily for chronic asthma for a mean of 16 years from childhood into adulthood didn't cause more cataracts or significantly change intraocular pressure or vision in a prospective, longitudinal, placebo-controlled study.
The combination of budesonide plus azathioprine achieves and maintains remission of autoimmune hepatitis as well as standard prednisone therapy does, while sparing patients many of the adverse effects of steroids, Dr.
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