The compound that is formed when inhaled carbon monoxide combines with hemoglobin, binding more tightly than oxygen and rendering the hemoglobin incapable of transporting oxygen.
Inhaled carbon monoxide also binds strongly to hemoglobin to form carboxyhemoglobin (COHb), preventing the transport of oxygen and can also bind to cytochrome oxidase, resulting in a decrease in oxygen uptake by cells.
A co-oxymeter is a spectrophotometer that measures light absorption at four different wavelengths and thus differentiates various forms of hemoglobin (oxyhemoglobin, deoxyhemoglobin, methemoglobin, and carboxyhemoglobin) (6).
We previously reported that arterial carboxyhemoglobin (CO-Hb, the end-product of heme metabolism) levels are elevated in patients with ILD, particularly during an AE, and these levels have been shown to correlate with parameters that reflect lung inflammation [19].
Initial labs revealed a WBC count of 21,000 with polymorphonuclear predominance of 81%, an elevated creatinine of 1.5mg/dL with no known baseline, BUN of 10mg/dL, GFR of 54 mL/min/1.73 [m.sup.2], lactic acidosis, creatine kinase of 350 U/L, and a carboxyhemoglobin level of 3.1%.
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.