The drugs were categorized into 5 distinct groups: metformin, glyburide, thiazolidinediones (pioglitazone, rosiglitazone), insulin and other oral hypoglycemic agents (
chlorpropamide, gliclazide, tolbutamide, glimepiride, sitagliptin, saxagliptin, nateglinide, repaglinide).
apocynaceae (Madagascar periwinkle) and
chlorpropamide (Diabenese) on alloxan-induced diabetic rats.
Remko [16] used the methods of theoretical chemistry to elucidate the molecular properties of the hypoglycemic sulfonylureas and glinides (acetohexamide, tolazamide, tolbutamide,
chlorpropamide, gliclazide, glimepiride, glipizide, glibenclamide, nateglinide, and repaglinide) which are known as antidiabetic molecules.
A wide variety of drugs are associated with SIADH, including
chlorpropamide, clofibrate, carbamazepine, vincristine, selective serotonin reuptake inhibitors, tricyclic anti-depressants, and NSAIDs [3].
Six drugs are included in this subclass:
chlorpropamide, glimepiride (Amaryl), glipizide (Glucotrol), glyburide, tolazamide (Tolinase), and tolbutamide.
Traditional sulfonylureas such as
chlorpropamide and glibenclamide, are either obsolete or rarely used now.
The urinary clearance of methotrexate, phenobarbital,
chlorpropamide, and fluoride is increased after reaching urinary pH levels of 7.5-8.0 via formation of lipid insoluble metabolite of the parent drug.
There are some cases in literature reporting use of alternative treatments like carbamazepine [20],
chlorpropamide [21,22], and clofibrate [21, 23] for management of central diabetes insipidus.
Sulfonylureas (e.g.,
chlorpropamide [Diabinese[R]]) should be avoided in Stages III-V renal disease.
Sulfonylureas
Chlorpropamide Simulate beta cells to (Diabenase[R]) release more insulin.
Inciting medications are often one of the following: chloramphenicol, ethambutol, isoniazid, digitalis, chloroquine, streptomycin,
chlorpropamide, ethchlorvynol, disulfiram, methanol, carbondioxide, amiodaroneandmetals such as lead.