A drug that binds to intestinal bile acids and promotes their excretion, used to lower serum cholesterol levels and to treat itching associated with partial biliary obstruction.
Recent research has shown that dietary fiber from green cabbage may be as effective as cholestyramine, a commonly prescribed drug to lower blood cholesterol levels, in reducing blood lipids.
The patient completed a 10-day course of doxycycline but unfortunately suffered from bile cast nephropathy from severe hyperbilirubinemia with continued rise in Cr (Figure 1(a)), for which he was treated with cholestyramine and ursodiol.
In this narrative review, we provide data about the mechanisms of action, indications, dosages, and side effects of NTADs that are currently used including iodine-containing compounds, lithium carbonate, perchlorate, glucocorticoids, and cholestyramine. Furthermore, we provide an up-to-date review of studies that have investigated drugs acting on the pathogenesis of GD including rituximab and treatment targeting the thyroid-stimulating hormone receptor (TSHR) as well as the future prospects for new therapies for GD that have not been mentioned together in previous reviews.
The BAS include colesevelam (Welchol, Daiichi Sankyo Inc, Tokyo, Japan), colestipol (Colestid, Pfizer Inc, New York, New York), and cholestyramine (LoCholest, Warner Chilcott Inc, Rockaway, New Jersey; Prevalite, Upsher-Smith Laboratories, Maple Grove, Minnesota; and Questran, Par Pharmaceutical, Woodcliff Lake, New Jersey).
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