A platinum-containing chemotherapeutic drug, Cl2H6N2Pt, used in the treatment of metastatic ovarian or testicular cancers and advanced bladder cancer. Also called cisplatinum.
(Pharmacology) a cytotoxic drug that acts by preventing DNA replication and hence cell division, used in the treatment of tumours, esp of the ovary and testis
Schornagel et al., "Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: european organization for research and treatment of cancer protocol no.
Randomized phase III trial of concurebt accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma:RTOG 0522.
Cisplatin-resistant sublines (SW480) were selected by double subcloning using the limiting dilution method from cultures continuously exposed to increasing concentrations of cisplatin (14).
Cisplatin plus ifosfamide-containing regimens form the backbone of salvage CDCT, with studies testing a variety of third drugs to add to this combination.
In the Phase Ib study of Acelarin combined with cisplatin, we observed an approximate doubling of the response rate expected with the standard of care, gemcitabine plus cisplatin, with several patients achieving significant reductions in their tumor volume as well as further tumor shrinkage over time.
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